James married Isabella Ann Sewell on 31 May 1846 in St Philip, Liverpool. Isabella (daughter of Thomas Sewell and Jane Whitelock) was born in 1825 in Wavertree, Liverpool. [Group Sheet] [Family Chart]

1. James Abernethy was born in 1847 in Liverpool.
2. Thomas Abernethy was born in 1849 in Liverpool; died before 1861.
3. Joseph Sewell Abernethy was born in 1854 in Liverpool; died before 1861.
4. Charles Louttit Abernethy was born in 1856 in Liverpool.
5. Jane Whitlock Abernethy was born in 1858 in Liverpool.
6. William Nealon Abernethy was born on 23 Apr 1861 in Liverpool.
7. Thomas Henry Abernethy was born on 28 Nov 1862 in Liverpool.
8. John Abernethy was born on 30 Jun 1864 in Liverpool.
9. Isabella A Abernethy was born in 1866 in Liverpool.
10. Maggie Abernethy was born in 1868 in Liverpool.
11. Alexander Wilson Abernethy was born in 1870 in Liverpool.
12. Mary E Abernethy was born in 1872 in Liverpool.
13. Frederick Abernethy was born in 1873 in Liverpool.